Analysis performed on 2024-07-10 11:38:18
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 46644 | 573 | 46071 | 26574 |
| Archaea | 3232 | 83 | 3149 | 1281 |
| Vertebrata | 1844 | 685 | 1159 | 434 |
| Mammals | 862 | 201 | 661 | 128 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 748 | 11 | 623 |
| Domains | |
|---|---|
| Current Study | 1, 20 | 644, 749 |
| Guo et al (2010) | 1, 82 | 201, 297 | 664, 748 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 623 | 125 | 748 | 4.984000 |
| Number of Variants | 522 | 112 | 634 | 4.660714 |
| Number of Pathogenic Variants | 9 | 2 | 11 | 4.500000 |
| Number of Benign/Unknown Variants | 513 | 110 | 623 | 4.663636 |
| Fisher exact test | 1.000000 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 484 | 264 | 748 | 1.833333 |
| Number of Variants | 415 | 219 | 634 | 1.894977 |
| Number of Pathogenic Variants | 10 | 1 | 11 | 10.000000 |
| Number of Benign/Unknown Variants | 405 | 218 | 623 | 1.857798 |
| Fisher exact test | 0.108010 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 623 | 125 | 0.81 (0.01) | 0.81 (0.01) | 8.051e-01 | 8.764e-01 | 40745.00 | 2.06e-01 |
| Guo et al (2010) | 484 | 264 | 0.80 (0.01) | 0.81 (0.01) | 8.031e-01 | 8.274e-01 | 62504.50 | 6.88e-01 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.